CD206/MRC1 (PT0527R) PT® Rabbit mAb
- Catalog No.:YM8349
- Applications:WB;IHC;IF;IP;ELISA
- Reactivity:Human; Mouse; Rat;
- Target:
- CD206
- Fields:
- >>Phagosome;>>Tuberculosis
- Gene Name:
- MRC1
- Protein Name:
- Macrophage mannose receptor 1
- Human Gene Id:
- 4360
- Human Swiss Prot No:
- P22897
- Mouse Gene Id:
- 17533
- Mouse Swiss Prot No:
- Q61830
- Specificity:
- endogenous
- Formulation:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
- Source:
- Monoclonal, rabbit, IgG, Kappa
- Dilution:
- IHC 1:200-1:1000;WB 1:5000-1:20000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
- Purification:
- Protein A
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Other Name:
- MRC1;CLEC13D;CLEC13DL;MRC1L1;Macrophage mannose receptor 1;MMR;C-type lectin domain family 13 member D;C-type lectin domain family 13 member D-like;Macrophage mannose receptor 1-like protein 1;CD206
- Molecular Weight(Da):
- 190kD
- Observed Band(KD):
- 190kD
- Background:
- The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Sep 2015],
- Function:
- function:Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens.,miscellaneous:CRDs 1-3 have at most very weak affinity for carbohydrate. CRD 4 shows the highest affinity binding and has multispecificity for a variety of monosaccharides. At least 3 CRDs (4, 5, and 7) are required for high affinity binding and endocytosis of multivalent glycoconjugates.,online information:Macrophage mannose receptor,similarity:Contains 1 fibronectin type-II domain.,similarity:Contains 1 ricin B-type lectin domain.,similarity:Contains 8 C-type lectin domains.,
- Subcellular Location:
- Membrane
- Expression:
- Milk,Placenta,Testis,
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Bruton’s tyrosine kinase-bearing B cells and microglia in neuromyelitis optica spectrum disorder Journal of Neuroinflammation Liu Ye IF Mouse 1:200 brain tissue
STING Agonist cGAMP Attenuates Sleep Deprivation-Induced Neuroinflammation and Cognitive Deficits via TREM2 Up-Regulation INFLAMMATION Wang Yue IF Mouse 1:50 hippocampal tissue
Targeted lung therapy with rosmarinic acid encapsulated in PLGA microspheres for radiation-induced pulmonary fibrosis JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY Yonglai Chen IHC Mouse 1:200 Lung tissue
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- Antibody-FAQs
- Products Images
- Various whole cell lysates were separated by 4-8% SDS-PAGE, and the membrane was blotted with anti-CD206/MRC1 (PT0527R) antibody. The HRP-conjugated Goat anti-Rabbit IgG(H + L) antibody was used to detect the antibody. Lane 1: Mouse liver Predicted band size: 190kDa Observed band size: 190kDa
- Human colon was stained with anti-CD206/MRC1 (PT0527R) rabbit antibody
- Human testis was stained with anti-CD206/MRC1 (PT0527R) rabbit antibody
- Mouse colon was stained with anti-CD206/MRC1 (PT0527R) rabbit antibody