PDE3A Polyclonal Antibody

  • Catalog No.：YN0061
  • Applications：WB;ELISA
  • Reactivity：Human;Mouse;Rat
    • Target：
    • PDE3A
    • Fields：
    • >>Purine metabolism;>>Metabolic pathways;>>cGMP-PKG signaling pathway;>>cAMP signaling pathway;>>Renin secretion;>>Morphine addiction
    • Gene Name：
    • PDE3A
    • Protein Name：
    • cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A)
    • Human Gene Id：
    • 5139
    • Human Swiss Prot No：
    • Q14432
    • Mouse Swiss Prot No：
    • Q9Z0X4
    • Immunogen：
    • Synthesized peptide derived from human protein . at AA range: 250-330
    • Specificity：
    • PDE3A Polyclonal Antibody detects endogenous levels of protein.
    • Formulation：
    • Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
    • Source：
    • Polyclonal, Rabbit,IgG
    • Dilution：
    • WB 1:500-2000 ELISA 1:5000-20000
    • Purification：
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • Concentration：
    • 1 mg/ml
    • Storage Stability：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Observed Band(KD)：
    • 125kD
    • Background：
    • This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011],
    • Function：
    • catalytic activity:Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.,enzyme regulation:Inhibited by cGMP.,function:Hydrolyzes both cyclic AMP (cAMP) and cyclic GMP (cGMP).,online information:PDE3 entry,similarity:Belongs to the cyclic nucleotide phosphodiesterase family.,
    • Subcellular Location：
    • Membrane ; Multi-pass membrane protein . Cytoplasm, cytosol .
    • Expression：
    • Blood,Epithelium,Liver,Myocardium,Penis,Platelet,

    Attributes

    • Code：
    • YN0061
    • Size
    • 40μL / 100μL / 200μL
    • Price$：
    • 150 / 280 / 450
    • Delivery：
    • 2024-12-24
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