• Target：
• FRAT1

• Fields：
• >>Wnt signaling pathway;>>Alzheimer disease;>>Pathways of neurodegeneration - multiple diseases;>>Pathways in cancer;>>Breast cancer;>>Hepatocellular carcinoma;>>Gastric cancer

• Gene Name：
• FRAT1

• Protein Name：
• Proto-oncogene FRAT1 (Frequently rearranged in advanced T-cell lymphomas 1) (FRAT-1)

• Human Gene Id：
• 10023

• Human Swiss Prot No：
• Q92837

• Mouse Swiss Prot No：
• P70339

• Immunogen：
• Synthesized peptide derived from human protein . at AA range: 130-210

• Specificity：
• FRAT1 Polyclonal Antibody detects endogenous levels of protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000 ELISA 1:5000-20000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Observed Band(KD)：
• 30kD

• Background：
• The protein encoded by this gene belongs to the GSK-3-binding protein family. The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. It may function in tumor progression and in lymphomagenesis. [provided by RefSeq, Oct 2008],

• Function：
• function:Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. May play a role in tumor progression and collaborate with PIM1 and MYC in lymphomagenesis.,PTM:Phosphorylated.,similarity:Belongs to the GSK-3-binding protein family.,subunit:Binds DVL1. Binds GSK-3 and prevent GSK-3-dependent phosphorylation.,

• Subcellular Location：
• Cytoplasm.

• Expression：
• Lung,Testis,

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