RAC3 Polyclonal Antibody

    • Catalog No.：YN1163
    • Applications：WB;ELISA
    • Reactivity：Human;Mouse
      • Target：
      • RAC3
      • Fields：
      • >>MAPK signaling pathway;>>Ras signaling pathway;>>Rap1 signaling pathway;>>cAMP signaling pathway;>>Chemokine signaling pathway;>>Sphingolipid signaling pathway;>>Wnt signaling pathway;>>Axon guidance;>>VEGF signaling pathway;>>Focal adhesion;>>Adherens junction;>>Natural killer cell mediated cytotoxicity;>>B cell receptor signaling pathway;>>Fc epsilon RI signaling pathway;>>Regulation of actin cytoskeleton;>>Yersinia infection;>>Human cytomegalovirus infection;>>Human immunodeficiency virus 1 infection;>>Pathways in cancer;>>Colorectal cancer;>>Pancreatic cancer;>>Choline metabolism in cancer;>>Viral myocarditis;>>Fluid shear stress and atherosclerosis
      • Gene Name：
      • RAC3
      • Protein Name：
      • Ras-related C3 botulinum toxin substrate 3 (p21-Rac3)
      • Human Gene Id：
      • 5881
      • Human Swiss Prot No：
      • P60763
      • Mouse Swiss Prot No：
      • P60764
      • Immunogen：
      • Synthesized peptide derived from human protein . at AA range: 80-160
      • Specificity：
      • RAC3 Polyclonal Antibody detects endogenous levels of protein.
      • Formulation：
      • Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
      • Source：
      • Polyclonal, Rabbit,IgG
      • Dilution：
      • WB 1:500-2000 ELISA 1:5000-20000
      • Purification：
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration：
      • 1 mg/ml
      • Storage Stability：
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Observed Band(KD)：
      • 21kD
      • Background：
      • The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015],
      • Function：
      • function:Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles.,induction:Expression down-regulated in quiescent fibroblasts and clearly induced by serum stimulation.,similarity:Belongs to the small GTPase superfamily. Rho family.,subcellular location:Membrane-associated when activated. Co-localizes with NRBP to endomembranes and at the cell periphery in lamellipodia.,subunit:Interacts with the GEF protein DOCK7, which promotes the exchange between GDP and GTP, and therefore activates it. Interacts with C1D.,tissue specificity:Highest levels in brain, also detected in heart, placenta and pancreas.,
      • Subcellular Location：
      • Cytoplasm. Endomembrane system. Cell projection, lamellipodium. Cytoplasm, perinuclear region. Cell membrane. Cytoplasm, cytoskeleton. Membrane-associated when activated. Colocalizes with NRBP to endomembranes and at the cell periphery in lamellipodia. Colocalized with CIB1 in the perinuclear area and at the cell periphery.
      • Expression：
      • Highest levels in brain, also detected in heart, placenta and pancreas.
      • Products Images
      • Western blot analysis of lysates from A431 cells, primary antibody was diluted at 1:1000, 4°over night

      Attributes

      • Code：
      • YN1163
      • Size
      • 40μL / 100μL / 200μL
      • Price$：
      • 150 / 280 / 450
      • Delivery：
      • 2024-12-23
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