SOCS4 Polyclonal Antibody

  • Catalog No.：YN1373
  • Applications：WB;ELISA
  • Reactivity：Human;Mouse
    • Target：
    • SOCS4
    • Fields：
    • >>JAK-STAT signaling pathway;>>Insulin signaling pathway;>>Prolactin signaling pathway;>>Type II diabetes mellitus
    • Gene Name：
    • SOCS4 SOCS7
    • Protein Name：
    • Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine signaling 7) (SOCS-7)
    • Human Swiss Prot No：
    • Q8WXH5
    • Mouse Swiss Prot No：
    • Q91ZA6
    • Immunogen：
    • Synthesized peptide derived from part region of human protein
    • Specificity：
    • SOCS4 Polyclonal Antibody detects endogenous levels of protein.
    • Formulation：
    • Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
    • Source：
    • Polyclonal, Rabbit,IgG
    • Dilution：
    • WB 1:500-2000 ELISA 1:5000-20000
    • Purification：
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • Concentration：
    • 1 mg/ml
    • Storage Stability：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Observed Band(KD)：
    • 48kD
    • Background：
    • The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008],
    • Function：
    • domain:The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.,function:SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SOCS box domain.,
    • Subcellular Location：
    • intracellular,cytoplasm,
    • Expression：
    • Endometrium carcinoma cell line,Neuroblastoma,Placenta,

    Attributes

    • Code：
    • YN1373
    • Size
    • 40μL / 100μL / 200μL
    • Price$：
    • 150 / 280 / 450
    • Delivery：
    • 2024-12-24
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