M3K14 Polyclonal Antibody
- Catalog No.:YN1594
- Applications:WB;ELISA
- Reactivity:Human;Mouse
- Target:
- M3K14
- Fields:
- >>MAPK signaling pathway;>>NF-kappa B signaling pathway;>>Apoptosis;>>Osteoclast differentiation;>>C-type lectin receptor signaling pathway;>>T cell receptor signaling pathway;>>TNF signaling pathway;>>Intestinal immune network for IgA production;>>Alcoholic liver disease;>>Epithelial cell signaling in Helicobacter pylori infection;>>Human T-cell leukemia virus 1 infection;>>Epstein-Barr virus infection;>>Chemical carcinogenesis - reactive oxygen species
- Gene Name:
- MAP3K14 NIK
- Protein Name:
- Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF-kappa-beta-inducing kinase) (HsNIK) (Serine/threonine-protein kinase NIK)
- Human Gene Id:
- 9020
- Human Swiss Prot No:
- Q99558
- Mouse Swiss Prot No:
- Q9WUL6
- Immunogen:
- Synthesized peptide derived from human protein . at AA range: 90-170
- Specificity:
- M3K14 Polyclonal Antibody detects endogenous levels of protein.
- Formulation:
- Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
- Source:
- Polyclonal, Rabbit,IgG
- Dilution:
- WB 1:500-2000 ELISA 1:5000-20000
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration:
- 1 mg/ml
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Observed Band(KD):
- 104kD
- Background:
- This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq, Jul 2008],
- Function:
- catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Induces the processing of NF-kappa-B 2/P100. Could act in a receptor-selective manner.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Binds to TRAF2, TRAF5, TRAF6, IKKA and NF-kappa-B 2/P100 (By similarity). Interacts with PELI3. Interacts with NIBP; the interaction is direct.,tissue specificity:Weakly expressed in testis, small intestine, spleen, thymus, peripheral blood leukocytes, prostate, ovary and colon.,
- Subcellular Location:
- Cytoplasm.
- Expression:
- Weakly expressed in testis, small intestine, spleen, thymus, peripheral blood leukocytes, prostate, ovary and colon.
- June 19-2018
- WESTERN IMMUNOBLOTTING PROTOCOL
- June 19-2018
- IMMUNOHISTOCHEMISTRY-PARAFFIN PROTOCOL
- June 19-2018
- IMMUNOFLUORESCENCE PROTOCOL
- September 08-2020
- FLOW-CYTOMEYRT-PROTOCOL
- May 20-2022
- Cell-Based ELISA│解您多样本WB检测之困扰
- July 13-2018
- CELL-BASED-ELISA-PROTOCOL-FOR-ACETYL-PROTEIN
- July 13-2018
- CELL-BASED-ELISA-PROTOCOL-FOR-PHOSPHO-PROTEIN
- July 13-2018
- Antibody-FAQs