ITA10 Polyclonal Antibody
- Catalog No.:YN1769
- Applications:WB;ELISA
- Reactivity:Human
- Target:
- ITA10
- Fields:
- >>PI3K-Akt signaling pathway;>>Focal adhesion;>>ECM-receptor interaction;>>Regulation of actin cytoskeleton;>>Human papillomavirus infection;>>Hypertrophic cardiomyopathy;>>Arrhythmogenic right ventricular cardiomyopathy;>>Dilated cardiomyopathy
- Gene Name:
- ITGA10 UNQ468/PRO827
- Protein Name:
- Integrin alpha-10
- Human Gene Id:
- 8515
- Human Swiss Prot No:
- O75578
- Immunogen:
- Synthesized peptide derived from part region of human protein
- Specificity:
- ITA10 Polyclonal Antibody detects endogenous levels of protein.
- Formulation:
- Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
- Source:
- Polyclonal, Rabbit,IgG
- Dilution:
- WB 1:500-2000 ELISA 1:5000-20000
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration:
- 1 mg/ml
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Observed Band(KD):
- 128kD
- Background:
- Integrins are integral transmembrane glycoproteins composed of noncovalently linked alpha and beta chains. They participate in cell adhesion as well as cell-surface mediated signalling. This gene encodes an integrin alpha chain and is expressed at high levels in chondrocytes, where it is transcriptionally regulated by AP-2epsilon and Ets-1. The protein encoded by this gene binds to collagen. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014],
- Function:
- domain:The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.,function:Integrin alpha-10/beta-1 is a receptor for collagen.,similarity:Belongs to the integrin alpha chain family.,similarity:Contains 1 VWFA domain.,similarity:Contains 7 FG-GAP repeats.,subunit:Heterodimer of an alpha and a beta subunit. Alpha-10 associates with beta-1.,tissue specificity:Widely expressed with highest expression in muscle and heart. Found in articular cartilage.,
- Subcellular Location:
- Membrane; Single-pass type I membrane protein.
- Expression:
- Widely expressed with highest expression in muscle and heart. Found in articular cartilage.
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