ITB8 Polyclonal Antibody
- Catalog No.:YN1771
- Applications:WB;ELISA
- Reactivity:Human;Mouse
- Target:
- ITB8
- Fields:
- >>PI3K-Akt signaling pathway;>>Focal adhesion;>>ECM-receptor interaction;>>Cell adhesion molecules;>>Regulation of actin cytoskeleton;>>Human papillomavirus infection;>>Hypertrophic cardiomyopathy;>>Arrhythmogenic right ventricular cardiomyopathy;>>Dilated cardiomyopathy
- Gene Name:
- ITGB8
- Protein Name:
- Integrin beta-8
- Human Gene Id:
- 3696
- Human Swiss Prot No:
- P26012
- Immunogen:
- Synthesized peptide derived from part region of human protein
- Specificity:
- ITB8 Polyclonal Antibody detects endogenous levels of protein.
- Formulation:
- Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
- Source:
- Polyclonal, Rabbit,IgG
- Dilution:
- WB 1:500-2000 ELISA 1:5000-20000
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration:
- 1 mg/ml
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Observed Band(KD):
- 84kD
- Background:
- This gene is a member of the integrin beta chain family and encodes a single-pass type I membrane protein with a VWFA domain and four cysteine-rich repeats. This protein noncovalently binds to an alpha subunit to form a heterodimeric integrin complex. In general, integrin complexes mediate cell-cell and cell-extracellular matrix interactions and this complex plays a role in human airway epithelial proliferation. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008],
- Function:
- function:Integrin alpha-V/beta-8 is a receptor for fibronectin.,similarity:Belongs to the integrin beta chain family.,similarity:Contains 1 VWFA domain.,subunit:Heterodimer of an alpha and a beta subunit. Beta-8 associates with alpha-V.,tissue specificity:Placenta, kidney, brain, ovary, uterus and in several transformed cells. Transiently expressed in 293 human embryonic kidney cells.,
- Subcellular Location:
- Cell membrane ; Single-pass type I membrane protein .
- Expression:
- Placenta, kidney, brain, ovary, uterus and in several transformed cells. Transiently expressed in 293 human embryonic kidney cells.
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