• Target：
• DKK2

• Fields：
• >>Wnt signaling pathway;>>Alzheimer disease;>>Pathways of neurodegeneration - multiple diseases

• Gene Name：
• DKK2 UNQ682/PRO1316

• Protein Name：
• Dickkopf-related protein 2 (Dickkopf-2) (Dkk-2) (hDkk-2)

• Human Gene Id：
• 27123

• Human Swiss Prot No：
• Q9UBU2

• Mouse Swiss Prot No：
• Q9QYZ8

• Immunogen：
• Synthesized peptide derived from part region of human protein

• Specificity：
• DKK2 Polyclonal Antibody detects endogenous levels of protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000 ELISA 1:5000-20000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Observed Band(KD)：
• 28kD

• Background：
• This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). [provided by RefSeq, Jul 2008],

• Function：
• function:Inhibitor of Wnt signaling pathway .,PTM:May be proteolytically processed by a furin-like protease.,similarity:Belongs to the dickkopf family.,tissue specificity:Expressed in heart, brain, skeletal muscle and lung.,

• Subcellular Location：
• Secreted.

• Expression：
• Expressed in heart, brain, skeletal muscle and lung.

Generation of a DKK2 homozygous knockout human embryonic stem cell line using the CRISPR/Cas9 system. Stem Cell Research Stem Cell Res. 2021 Dec;57:102611 ICC Human 1:300 hESCs

ARHGAP9 knockdown promotes lung adenocarcinoma metastasis by activating Wnt/β-catenin signaling pathway via suppressing DKK2. Wenzhou Zhang WB Human 1:1000 H1299 cell

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