PTPRF Polyclonal Antibody

  • Catalog No.：YN2203
  • Applications：WB;ELISA
  • Reactivity：Human;Rat;Mouse
    • Target：
    • PTPRF
    • Fields：
    • >>Cell adhesion molecules;>>Adherens junction;>>Insulin signaling pathway;>>Insulin resistance
    • Gene Name：
    • PTPRF LAR
    • Protein Name：
    • Receptor-type tyrosine-protein phosphatase F (EC 3.1.3.48) (Leukocyte common antigen related) (LAR)
    • Human Gene Id：
    • 5792
    • Human Swiss Prot No：
    • P10586
    • Mouse Swiss Prot No：
    • A2A8L5
    • Immunogen：
    • Synthesized peptide derived from part region of human protein
    • Specificity：
    • PTPRF Polyclonal Antibody detects endogenous levels of protein.
    • Formulation：
    • Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
    • Source：
    • Polyclonal, Rabbit,IgG
    • Dilution：
    • WB 1:500-2000 ELISA 1:5000-20000
    • Purification：
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • Concentration：
    • 1 mg/ml
    • Storage Stability：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Observed Band(KD)：
    • full lenth:209kD, Mature:140-150kD
    • Background：
    • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pat
    • Function：
    • catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,function:Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase).,function:The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.,similarity:Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.,similarity:Contains 2 tyrosine-protein phosphatase domains.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,similarity:Contains 8 fibronectin type-III domains.,subunit:Interacts with GRIP1 (By similarity). Interacts with PPFIA1, PPFIA2 and PPFIA3.,
    • Subcellular Location：
    • Membrane; Single-pass type I membrane protein.
    • Expression：
    • Brain,Human cervix,Plasma,Retinoblastoma,Tonsil,

    Attributes

    • Code：
    • YN2203
    • Size
    • 40μL / 100μL / 200μL
    • Price$：
    • 150 / 280 / 450
    • Delivery：
    • 2024-12-23
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