NRG4 Polyclonal Antibody
- Catalog No.:YN2440
- Applications:WB;ELISA
- Reactivity:Human;Mouse
- Target:
- NRG4
- Fields:
- >>ErbB signaling pathway;>>Amyotrophic lateral sclerosis
- Gene Name:
- NRG4
- Protein Name:
- Pro-neuregulin-4, membrane-bound isoform (Pro-NRG4) [Cleaved into: Neuregulin-4 (NRG-4)]
- Human Gene Id:
- 145957
- Human Swiss Prot No:
- Q8WWG1
- Mouse Swiss Prot No:
- Q9WTX4
- Immunogen:
- Synthesized peptide derived from human protein . at AA range: 11-60
- Specificity:
- NRG4 Polyclonal Antibody detects endogenous levels of protein.
- Formulation:
- Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
- Source:
- Polyclonal, Rabbit,IgG
- Dilution:
- WB 1:500-2000 ELISA 1:5000-20000
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration:
- 1 mg/ml
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Observed Band(KD):
- 12kD
- Background:
- The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]).[supplied by OMIM, Mar 2008],
- Function:
- domain:ERBB receptor binding is elicited entirely by the EGF-like domain.,domain:The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization.,function:Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors.,PTM:Extensive glycosylation precedes the proteolytic cleavage.,PTM:Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.,similarity:Belongs to the neuregulin family.,similarity:Contains 1 EGF-like domain.,subcellular location:Does not seem to be active.,
- Subcellular Location:
- [Pro-neuregulin-4, membrane-bound isoform]: Cell membrane ; Single-pass type I membrane protein . Does not seem to be active. .; [Neuregulin-4]: Secreted .
- Expression:
- Breast,Liver,Prostate,
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- Antibody-FAQs
- Products Images
- Western blot analysis of lysates from DU145 cells, primary antibody was diluted at 1:1000, 4°over night