DLG1 Polyclonal Antibody

  • Catalog No.：YN2821
  • Applications：WB;ELISA
  • Reactivity：Human;Rat;Mouse;
    • Target：
    • DLG1
    • Fields：
    • >>Hippo signaling pathway;>>Tight junction;>>T cell receptor signaling pathway;>>Human papillomavirus infection;>>Human T-cell leukemia virus 1 infection;>>Viral carcinogenesis
    • Gene Name：
    • DLG1
    • Protein Name：
    • Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (SAP97) (hDlg)
    • Human Gene Id：
    • 1739
    • Human Swiss Prot No：
    • Q12959
    • Mouse Swiss Prot No：
    • Q811D0
    • Immunogen：
    • Synthesized peptide derived from part region of human protein AA range: 70-120
    • Specificity：
    • DLG1 Polyclonal Antibody detects endogenous levels of protein.
    • Formulation：
    • Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
    • Source：
    • Polyclonal, Rabbit,IgG
    • Dilution：
    • WB 1:500-2000 ELISA 1:5000-20000
    • Purification：
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • Concentration：
    • 1 mg/ml
    • Storage Stability：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Observed Band(KD)：
    • 99kD
    • Background：
    • This gene encodes a multi-domain scaffolding protein that is required for normal development. This protein may have a role in septate junction formation, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene, but the full-length nature of some of the variants is not known. [provided by RefSeq, Feb 2011],
    • Function：
    • domain:The alternatively spliced domain I3 corresponding to amino acids (636-669) of isoform 4 is an EPB41 binding site mediating association to membranes in polarized and non-polarized cells.,domain:The L27 domain may regulate DLG1 self-association. The N-terminal alternatively spliced region is capable of binding several SH3 domains and also moderates the level of protein oligomerization.,domain:The PDZ domains may also mediate association to membranes by binding to EPB41 and GPR124 together with the L27 domain that binds CASK and DLG2.,function:Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the ex
    • Subcellular Location：
    • Membrane ; Peripheral membrane protein . Basolateral cell membrane . Endoplasmic reticulum membrane . Cell junction, synapse, postsynaptic density . Cell junction, synapse . Cell membrane, sarcolemma . Apical cell membrane . Cell junction . Cytoplasm . Colocalizes with EPB41 at regions of intercellular contacts. Basolateral in epithelial cells (PubMed:12807908). May also associate with endoplasmic reticulum membranes. Mainly found in neurons soma, moderately found at postsynaptic densities (By similarity). .
    • Expression：
    • Abundantly expressed in atrial myocardium (at protein level). Expressed in lung fibroblasts, cervical epithelial and B-cells (at protein level). Expressed in the brain (at protein level) (PubMed:23676497). Widely expressed, with isoforms displaying different expression profiles.

    Attributes

    • Code：
    • YN2821
    • Size
    • 40μL / 100μL / 200μL
    • Price$：
    • 150 / 280 / 450
    • Delivery：
    • 2024-12-24
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