STAM1 Polyclonal Antibody

  • Catalog No.:YN2826
  • Applications:WB;ELISA
  • Reactivity:Human;Rat;Mouse;
    • Target:
    • STAM1
    • Fields:
    • >>Endocytosis;>>JAK-STAT signaling pathway
    • Gene Name:
    • STAM STAM1
    • Protein Name:
    • Signal transducing adapter molecule 1 (STAM-1)
    • Human Gene Id:
    • 8027
    • Human Swiss Prot No:
    • Q92783
    • Mouse Swiss Prot No:
    • P70297
    • Immunogen:
    • Synthesized peptide derived from part region of human protein AA range: 156-206
    • Specificity:
    • STAM1 Polyclonal Antibody detects endogenous levels of protein.
    • Formulation:
    • Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
    • Source:
    • Polyclonal, Rabbit,IgG
    • Dilution:
    • WB 1:500-2000 ELISA 1:5000-20000
    • Purification:
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • Concentration:
    • 1 mg/ml
    • Storage Stability:
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Observed Band(KD):
    • 59kD
    • Background:
    • This gene encodes a member of the signal-transducing adaptor molecule family. These proteins mediate downstream signaling of cytokine receptors and also play a role in ER to Golgi trafficking by interacting with the coat protein II complex. The encoded protein also associates with hepatocyte growth factor-regulated substrate to form the endosomal sorting complex required for transport-0 (ESCRT-0), which sorts ubiquitinated membrane proteins to the ESCRT-1 complex for lysosomal degradation. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011],
    • Function:
    • function:Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and c-myc induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.,PTM:Phosphorylated on Tyr-198. Phosphorylation occurs in response to IL-2, IL-3, IL-4, IL-7, GM-CSF, EGF and PDGF.,similarity:Belongs to the STAM family.,similarity:Contains 1 ITAM domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 1 UIM (ubiquitin-interacting motif) repeat.,similarity:Contains 1 VHS domain.,subunit:Com
    • Subcellular Location:
    • Cytoplasm . Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side .
    • Expression:
    • Ubiquitously expressed.