CAN1 Polyclonal Antibody

  • Catalog No.：YN2848
  • Applications：WB;ELISA
  • Reactivity：Human;Mouse;Rat
    • Target：
    • CAN1
    • Fields：
    • >>Protein processing in endoplasmic reticulum;>>Apoptosis;>>Necroptosis;>>Cellular senescence;>>Alzheimer disease;>>Pathways of neurodegeneration - multiple diseases;>>Shigellosis
    • Gene Name：
    • CAPN1 CANPL1 PIG30
    • Protein Name：
    • Calpain-1 catalytic subunit (EC 3.4.22.52) (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (Calpain-1 large subunit) (Cell proliferation-inducing gene 30 protein) (Micromolar-calpa
    • Human Gene Id：
    • 823
    • Human Swiss Prot No：
    • P07384
    • Mouse Swiss Prot No：
    • O35350
    • Immunogen：
    • Synthesized peptide derived from part region of human protein
    • Specificity：
    • CAN1 Polyclonal Antibody detects endogenous levels of protein.
    • Formulation：
    • Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
    • Source：
    • Polyclonal, Rabbit,IgG
    • Dilution：
    • WB 1:500-2000 ELISA 1:5000-20000
    • Purification：
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • Concentration：
    • 1 mg/ml
    • Storage Stability：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Observed Band(KD)：
    • 78kD
    • Background：
    • The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010],
    • Function：
    • catalytic activity:Broad endopeptidase specificity.,cofactor:Binds 3 calcium ions.,enzyme regulation:Activated by micromolar concentrations of calcium and inhibited by calpastatin.,function:Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.,online information:Calpain,similarity:Belongs to the peptidase C2 family.,similarity:Contains 1 calpain catalytic domain.,similarity:Contains 4 EF-hand domains.,subcellular location:Translocates to the plasma membrane upon Ca(2+) binding.,subunit:Forms a heterodimer with a small (regulatory) subunit (CAPNS1).,tissue specificity:Ubiquitous.,
    • Subcellular Location：
    • Cytoplasm . Cell membrane . Translocates to the plasma membrane upon Ca(2+) binding. In granular keratinocytes and in lower corneocytes, colocalizes with FLG and FLG2 (PubMed:21531719). .
    • Expression：
    • Ubiquitous.

    Attributes

    • Code：
    • YN2848
    • Size
    • 40μL / 100μL / 200μL
    • Price$：
    • 150 / 280 / 450
    • Delivery：
    • 2024-12-23
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