• Target：
• OSR1

• Gene Name：
• OXSR1

• Protein Name：
• Serine/threonine-protein kinase OSR1

• Human Gene Id：
• 9943

• Human Swiss Prot No：
• O95747

• Mouse Gene Id：
• 108737

• Mouse Swiss Prot No：
• Q6P9R2

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human OSR1 around the phosphorylation site of Thr185. AA range:151-200

• Specificity：
• Phospho-OSR1 (T185) Polyclonal Antibody detects endogenous levels of OSR1 protein only when phosphorylated at T185.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• OXSR1;KIAA1101;OSR1;Serine/threonine-protein kinase OSR1;Oxidative stress-responsive 1 protein

• Observed Band(KD)：
• 65kD

• Background：
• The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton. [provided by RefSeq, Jul 2008],

• Function：
• catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:By autophosphorylation on threonine.,function:Regulates downstream kinases in response to environmental stress. May also have a function in regulating the actin cytoskeleton.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Binds to and phosphorylates PAK1. Interacts with chloride channel proteins SLC12A6 isoform 2, SLC12A1 and SLC12A2 but not with SLC12A4 and SLC12A7, possibly establishing sensor/signaling modules that initiate the cellular response to environmental stress. Binds to and phosphorylates RELL1, RELL2 AND RELT.,tissue specificity:Ubiquitously expressed in all tissue examined.,

• Subcellular Location：
• Cytoplasm .

• Expression：
• Ubiquitously expressed in all tissue examined.

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