53BP1 (Phospho Ser1618) rabbit pAb

  • Catalog No.：YP1253
  • Applications：WB
  • Reactivity：Human;Rat
    • Target：
    • 53BP1
    • Fields：
    • >>NOD-like receptor signaling pathway
    • Gene Name：
    • TP53BP1
    • Protein Name：
    • 53BP1 (Ser1618)
    • Human Gene Id：
    • 7158
    • Human Swiss Prot No：
    • Q12888
    • Mouse Swiss Prot No：
    • P70399
    • Immunogen：
    • Synthesized phosho peptide around human 53BP1 (Ser1618)
    • Specificity：
    • This antibody detects endogenous levels of Human Rat 53BP1 (phospho-Ser1618)
    • Formulation：
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source：
    • Polyclonal, Rabbit,IgG
    • Dilution：
    • WB 1:1000-2000
    • Purification：
    • The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
    • Concentration：
    • 1 mg/ml
    • Storage Stability：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Other Name：
    • Tumor suppressor p53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1)
    • Observed Band(KD)：
    • 213kD
    • Function：
    • function:May have a role in checkpoint signaling during mitosis (By similarity). Enhances TP53-mediated transcriptional activation. Plays a role in the response to DNA damage.,PTM:Asymmetrically dimethylated on Arg residues by PRMT1. Methylation is required for DNA binding.,PTM:Phosphorylated at basal level in the absence of DNA damage. Hyper-phosphorylated in an ATM-dependent manner in response to DNA damage induced by ionizing radiation. Hyper-phosphorylated in an ATR-dependent manner in response to DNA damage induced by UV irradiation.,similarity:Contains 2 BRCT domains.,subcellular location:Associated with kinetochores. Both nuclear and cytoplasmic in some cells. Recruited to sites of DNA damage, such as double stand breaks. Methylation of histone H4 at 'Lys-20' is required for efficient localization to double strand breaks.,subunit:Interacts with IFI202A (By similarity). Binds to th
    • Subcellular Location：
    • Nucleus . Chromosome . Chromosome, centromere, kinetochore . Localizes to the nucleus in absence of DNA damage (PubMed:28241136). Following DNA damage, recruited to sites of DNA damage, such as double stand breaks (DSBs): recognizes and binds histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:23333306, PubMed:23760478, PubMed:24703952, PubMed:28241136, PubMed:17190600). Associated with kinetochores during mitosis (By similarity). .
    • Expression：
    • Cerebellum,Cervix,Epithelium,Myeloid leukemia cell,Skeletal muscle,

    Attributes

    • Code：
    • YP1253
    • Size
    • 50μL / 100μL / 200μL
    • Price$：
    • 190 / 340 / 600
    • Delivery：
    • 2024-11-24
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