CDC20 (Phospho Ser51) rabbit pAb

  • Catalog No.：YP1294
  • Applications：WB
  • Reactivity：Human;Mouse
    • Target：
    • CDC20
    • Fields：
    • >>Cell cycle;>>Oocyte meiosis;>>Ubiquitin mediated proteolysis;>>Human T-cell leukemia virus 1 infection;>>Viral carcinogenesis
    • Gene Name：
    • CDC20
    • Protein Name：
    • CDC20 (Ser51)
    • Human Gene Id：
    • 991
    • Human Swiss Prot No：
    • Q12834
    • Mouse Swiss Prot No：
    • Q9JJ66
    • Immunogen：
    • Synthesized phosho peptide around human CDC20 (Ser51)
    • Specificity：
    • This antibody detects endogenous levels of Human Mouse CDC20 (phospho-Ser51)
    • Formulation：
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source：
    • Polyclonal, Rabbit,IgG
    • Dilution：
    • WB 1:1000-2000
    • Purification：
    • The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
    • Concentration：
    • 1 mg/ml
    • Storage Stability：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Other Name：
    • Cell division cycle protein 20 homolog (p55CDC)
    • Observed Band(KD)：
    • 50kD
    • Background：
    • CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes, nuclear movement prior to anaphase and chromosome separation. [provided by RefSeq, Jul 2008],
    • Function：
    • developmental stage:Synthesis is initiated at G1/S, protein level peaks in M phase and protein is abruptly degraded at M/G1 transition.,function:Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1. In metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates.,pathway:Protein modification; protein ubiquitination.,PTM:Phosphorylated during mitosis, probably by maturation promoting factor (MPF).,PTM:Ubiquitinated and degraded by the proteasome during spindle assembly checkpoint.,similarity:Belongs to the WD repeat CDC20/Fizzy family.,similarity:Contains 7 WD repeats.,subunit:Found in a complex with CDC20, CDC27, SPATC1 and TUBG1. Interacts with SPATC1 (By similarity). Interacts with MAD2L
    • Subcellular Location：
    • Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle pole .
    • Expression：
    • Colon,Colon adenocarcinoma,Liver,Lymph,Muscle,Ovary,Skin,Spleen,Testis,

    Attributes

    • Code：
    • YP1294
    • Size
    • 50μL / 100μL / 200μL
    • Price$：
    • 190 / 340 / 600
    • Delivery：
    • 2024-11-23
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