TACC3 (Phospho Ser558) rabbit pAb

  • Catalog No.:YP1521
  • Applications:WB
  • Reactivity:Human;Rat;Mouse;
    • Target:
    • TACC3
    • Gene Name:
    • TACC3 ERIC1
    • Protein Name:
    • TACC3 (Ser558)
    • Human Swiss Prot No:
    • Q9Y6A5
    • Mouse Swiss Prot No:
    • Q9JJ11
    • Immunogen:
    • Synthesized phosho peptide around human TACC3 (Ser558)
    • Specificity:
    • This antibody detects endogenous levels of Human TACC3 (phospho-Ser558)
    • Formulation:
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source:
    • Polyclonal, Rabbit,IgG
    • Dilution:
    • WB 1:1000-2000
    • Purification:
    • The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
    • Concentration:
    • 1 mg/ml
    • Storage Stability:
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Other Name:
    • Transforming acidic coiled-coil-containing protein 3 (ERIC-1)
    • Observed Band(KD):
    • 80kD
    • Background:
    • This gene encodes a member of the transforming acidic colied-coil protein family. The encoded protein is a motor spindle protein that may play a role in stabilization of the mitotic spindle. This protein may also play a role in growth a differentiation of certain cancer cells. [provided by RefSeq, Nov 2011],
    • Function:
    • function:Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May be involved in the control of cell growth and differentiation. May contribute to cancer.,induction:Up-regulated in various cancer cell lines.,similarity:Belongs to the TACC family.,subunit:Interacts with microtubules. Interacts with CCDC100/CEP120. The coiled coil C-terminus region interacts with AH receptor nuclear translocator protein (ARNT) and ARNT2 (By similarity). Interacts with GCN5L2 and PCAF.,
    • Subcellular Location:
    • Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle . Cytoplasm, cytoskeleton, spindle pole . In complex with CKAP5 localized to microtubule plus-ends in mitosis and interphase. In complex with CKAP5 and clathrin localized to inter-microtubule bridges in mitotic spindles. .
    • Expression:
    • Epithelium,PCR rescued clones,Skin,