• Target：
• ULK1

• Fields：
• >>Mitophagy - animal;>>Autophagy - animal;>>mTOR signaling pathway;>>AMPK signaling pathway;>>Longevity regulating pathway;>>Alzheimer disease;>>Amyotrophic lateral sclerosis;>>Huntington disease;>>Spinocerebellar ataxia;>>Pathways of neurodegeneration - multiple diseases

• Gene Name：
• ULK1 KIAA0722

• Protein Name：
• ULK1 (Ser757)

• Human Gene Id：
• 8408

• Human Swiss Prot No：
• O75385

• Mouse Gene Id：
• 22241

• Mouse Swiss Prot No：
• O70405

• Immunogen：
• Synthesized phosho peptide around human ULK1 (Ser757)

• Specificity：
• This antibody detects endogenous levels of Human Mouse Rat ULK1 (phospho-Ser757)

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:1000-2000

• Purification：
• The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1)

• Observed Band(KD)：
• 115kD

• Function：
• catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Involved in axon growth. Plays an essential role in neurite extension of cerebellar granule cells.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with GABARAP and GABARAPL2.,tissue specificity:Ubiquitously expressed. Detected in the following adult tissues: skeletal muscle, heart, pancreas, brain, placenta, liver, kidney, and lung.,

• Subcellular Location：
• Cytoplasm, cytosol . Preautophagosomal structure . Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane that sequesters a portion of the cytoplasm resulting in the formation of an autophagosome. .

• Expression：
• Ubiquitously expressed. Detected in the following adult tissues: skeletal muscle, heart, pancreas, brain, placenta, liver, kidney, and lung.

Ferritinophagy is involved in Bisphenol A-induced ferroptosis of renal tubular epithelial cells through the activation of the AMPK-mTOR-ULK1 pathway Food Chem Toxicol. 2022 May;163:112909. WB Mouse kidney tissue

Luteolin and Exercise Combination Therapy Ameliorates Amyloid-β 1-42 Oligomers-Induced Cognitive Impairment in Alzheimer’s Disease Mice by Mediating Neuroinflammation and Autophagy JOURNAL OF ALZHEIMERS DISEASE Gong Weijun WB Mouse hippocampus tissues,cortex tissues

Resveratrol attenuates inflammation and fibrosis in rheumatoid arthritis-associated interstitial lung disease via the AKT/TMEM175 pathway Journal of Translational Medicine Liu Nannan WB Human,Mouse lung tissue MRC-5 cell

JAK2 inhibitor protects the septic heart through enhancing mitophagy in cardiomyocytes BIOMEDICINE & PHARMACOTHERAPY Dafei Han WB Mouse,Human heart tissue AC16 cell

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