AXL (Phospho Tyr697) rabbit pAb

  • Catalog No.：YP1605
  • Applications：WB;ELISA
  • Reactivity：Human;Mouse;Rat
    • Target：
    • AXL
    • Fields：
    • >>EGFR tyrosine kinase inhibitor resistance
    • Gene Name：
    • AXL UFO
    • Protein Name：
    • AXL (Phospho Tyr697)
    • Human Gene Id：
    • 558
    • Human Swiss Prot No：
    • P30530
    • Mouse Swiss Prot No：
    • Q00993
    • Immunogen：
    • Synthesized peptide derived from human AXL (Phospho Tyr697)
    • Specificity：
    • This antibody detects endogenous levels of Human,Mouse,Rat AXL (Phospho Tyr697)
    • Formulation：
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source：
    • Polyclonal, Rabbit,IgG
    • Dilution：
    • WB 1:1000-2000 ELISA 1:5000-20000
    • Purification：
    • The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
    • Concentration：
    • 1 mg/ml
    • Storage Stability：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Other Name：
    • Tyrosine-protein kinase receptor UFO (EC 2.7.10.1;AXL oncogene)
    • Observed Band(KD)：
    • 130kD
    • Background：
    • The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013],
    • Function：
    • catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:Has transforming potential in patients with chronic myeloproliferative disorder or chronic myelocytic leukemia.,function:May function as a signal transducer between specific cell types of mesodermal origin. In case of filovirus infection, seems to function as a cell entry factor.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 fibronectin type-III domains.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Heterodimer and heterotetramer with GAS6.,tissue specificity:Highly expressed in metastatic colon tumors. Expressed in primary colon tumors. Weakly expressed in normal colon tissue.,
    • Subcellular Location：
    • Cell membrane ; Single-pass type I membrane protein .
    • Expression：
    • Highly expressed in metastatic colon tumors. Expressed in primary colon tumors. Weakly expressed in normal colon tissue.

    Attributes

    • Code：
    • YP1605
    • Size
    • 50μL / 100μL / 200μL
    • Price$：
    • 190 / 340 / 600
    • Delivery：
    • 2024-11-23
    Order

    Related Products