EPHA2 (Phospho Tyr930) Rabbit pAb

  • Catalog No.：YP1818
  • Applications：IHC;WB
  • Reactivity：Human;Mouse
    • Target：
    • EphA2
    • Fields：
    • >>MAPK signaling pathway;>>Ras signaling pathway;>>Rap1 signaling pathway;>>PI3K-Akt signaling pathway;>>Axon guidance
    • Gene Name：
    • EPHA2 ECK
    • Protein Name：
    • Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
    • Human Gene Id：
    • 1969
    • Human Swiss Prot No：
    • P29317
    • Mouse Swiss Prot No：
    • Q03145
    • Immunogen：
    • Synthesized peptide derived from human EPHA2 (Phospho Tyr930)
    • Specificity：
    • This antibody detects endogenous levels of EPHA2 (Phospho Tyr930) Rabbit pAb at Human, Mouse
    • Formulation：
    • Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
    • Source：
    • Rabbit,polyclonal
    • Dilution：
    • WB 1:500-2000 IHC 1:50-200
    • Purification：
    • The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
    • Concentration：
    • 1 mg/ml
    • Storage Stability：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Other Name：
    • Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
    • Observed Band(KD)：
    • 130kD
    • Background：
    • EPH receptor A2(EPHA2) Homo sapiens This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.[provided by RefSeq, May 2010],
    • Function：
    • catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A3, -A4 and -A5.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 2 fibronectin type-III domains.,subunit:Interacts with SLA (By similarity). Interacts with INPPL1/SHIP2.,tissue specificity:Expressed most highly in tissues that contain a high proportion of epithelial cells, e.g., skin, intestine, lung, and ovary.,
    • Subcellular Location：
    • Cell membrane ; Single-pass type I membrane protein . Cell projection, ruffle membrane ; Single-pass type I membrane protein . Cell projection, lamellipodium membrane ; Single-pass type I membrane protein . Cell junction, focal adhesion . Present at regions of cell-cell contacts but also at the leading edge of migrating cells (PubMed:19573808, PubMed:20861311). Relocates from the plasma membrane to the cytoplasmic and perinuclear regions in cancer cells (PubMed:18794797). .
    • Expression：
    • Expressed in brain and glioma tissue and glioma cell lines (at protein level). Expressed most highly in tissues that contain a high proportion of epithelial cells, e.g. skin, intestine, lung, and ovary.

    Attributes

    • Code：
    • YP1818
    • Size
    • 50μL / 100μL / 200μL
    • Price$：
    • 300 / 560 / 936
    • Delivery：
    • 2024-11-23
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