ATP-citrate synthase Polyclonal Antibody

  • Catalog No.：YT0415
  • Applications：WB;IF;ELISA
  • Reactivity：Human;Mouse;Rat;Monkey
    • Target：
    • ATP-citrate synthase
    • Fields：
    • >>Citrate cycle (TCA cycle);>>Metabolic pathways
    • Gene Name：
    • ACLY
    • Protein Name：
    • ATP-citrate synthase
    • Human Gene Id：
    • 47
    • Human Swiss Prot No：
    • P53396
    • Mouse Swiss Prot No：
    • Q91V92
    • Immunogen：
    • The antiserum was produced against synthesized peptide derived from human ATP-Citrate Lyase. AA range:420-469
    • Specificity：
    • ATP-citrate synthase Polyclonal Antibody detects endogenous levels of ATP-citrate synthase protein.
    • Formulation：
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source：
    • Polyclonal, Rabbit,IgG
    • Dilution：
    • WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
    • Purification：
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • Concentration：
    • 1 mg/ml
    • Storage Stability：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Other Name：
    • ACLY;ATP-citrate synthase;ATP-citrate;pro-S-)-lyase;ACL;Citrate cleavage enzyme
    • Observed Band(KD)：
    • 120kD
    • Background：
    • ATP citrate lyase(ACLY) Homo sapiens ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014],
    • Function：
    • catalytic activity:ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA.,function:ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.,similarity:In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.,similarity:In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.,subunit:Homotetramer.,
    • Subcellular Location：
    • Cytoplasm, cytosol .
    • Expression：
    • Brain,Epithelium,Hippocampus,Liver,Lymph,Platelet,

    Attributes

    • Code：
    • YT0415
    • Size
    • 40μL / 100μL / 200μL
    • Price$：
    • 150 / 280 / 450
    • Delivery：
    • 2025-01-10
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