• Target：
• Brn-3a

• Gene Name：
• POU4F1

• Protein Name：
• POU domain class 4 transcription factor 1

• Human Gene Id：
• 5457

• Human Swiss Prot No：
• Q01851

• Mouse Gene Id：
• 18996

• Mouse Swiss Prot No：
• P17208

• Rat Swiss Prot No：
• P20266

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human POU4F1. AA range:311-360

• Specificity：
• Brn-3a Polyclonal Antibody detects endogenous levels of Brn-3a protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• POU4F1;BRN3A;RDC1;POU domain; class 4, transcription factor 1;Brain-specific homeobox/POU domain protein 3A;Brain-3A;Brn-3A;Homeobox/POU domain protein RDC-1;Oct-T1

• Observed Band(KD)：
• 42kD

• Background：
• This gene encodes a member of the POU-IV class of neural transcription factors. This protein is expressed in a subset of retinal ganglion cells and may be involved in the developing sensory nervous system. This protein may also promote the growth of cervical tumors. A translocation of this gene is associated with some adult acute myeloid leukemias. [provided by RefSeq, Mar 2012],

• Function：
• developmental stage:Expression peaks early in embryogenesis (day 13.5) and is undetectable 14 days after birth.,function:Probable transcription factor which may play a role in the regulation of specific gene expression within a subset of neuronal lineages. May play a role in determining or maintaining the identities of a small subset of visual system neurons.,similarity:Belongs to the POU transcription factor family. Class-4 subfamily.,similarity:Contains 1 homeobox DNA-binding domain.,similarity:Contains 1 POU-specific domain.,tissue specificity:Brain. Seems to be specific to the retina. Present in the developing brain, spinal cord and eye.,

• Subcellular Location：
• Nucleus . Cytoplasm .

• Expression：
• Expressed in the brain and the retina. Present in the developing brain, spinal cord and eye.

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