• Target：
• CD57

• Fields：
• >>Mannose type O-glycan biosynthesis;>>Metabolic pathways

• Gene Name：
• B3GAT1

• Protein Name：
• Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

• Human Gene Id：
• 27087

• Human Swiss Prot No：
• Q9P2W7

• Mouse Swiss Prot No：
• Q9CW73

• Rat Gene Id：
• 117108

• Rat Swiss Prot No：
• O35789

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human CD57. AA range:35-84

• Specificity：
• CD57 Polyclonal Antibody detects endogenous levels of CD57 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• B3GAT1;GLCATP;Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1;Beta-1;3-glucuronyltransferase 1;Glucuronosyltransferase P;GlcAT-P;UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase;GlcUAT-P

• Molecular Weight(Da)：
• 38kD

• Background：
• The protein encoded by this gene is a member of the glucuronyltransferase gene family. These enzymes exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages. This gene product functions as the key enzyme in a glucuronyl transfer reaction during the biosynthesis of the carbohydrate epitope HNK-1 (human natural killer-1, also known as CD57 and LEU7). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008],

• Function：
• catalytic activity:UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein.,cofactor:Manganese.,function:Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group.,online information:GlycoGene database,pathway:Protein modification; protein glycosylation.,similarity:Belongs to th

• Subcellular Location：
• [Isoform 1]: Golgi apparatus membrane ; Single-pass type II membrane protein . Secreted .; [Isoform 2]: Golgi apparatus membrane ; Single-pass type II membrane protein . Endoplasmic reticulum membrane . Secreted .

• Expression：
• Mainly expressed in the brain.

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