• Target：
• CstF-50

• Fields：
• >>mRNA surveillance pathway

• Gene Name：
• CSTF1

• Protein Name：
• Cleavage stimulation factor subunit 1

• Human Gene Id：
• 1477

• Human Swiss Prot No：
• Q05048

• Mouse Gene Id：
• 67337

• Mouse Swiss Prot No：
• Q99LC2

• Rat Gene Id：
• 311670

• Rat Swiss Prot No：
• Q5BJQ6

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human CSTF1. AA range:1-50

• Specificity：
• CstF-50 Polyclonal Antibody detects endogenous levels of CstF-50 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• CSTF1;Cleavage stimulation factor subunit 1;CF-1 50 kDa subunit;Cleavage stimulation factor 50 kDa subunit;CSTF 50 kDa subunit;CstF-50

• Observed Band(KD)：
• 48kD

• Background：
• This gene encodes one of three subunits which combine to form cleavage stimulation factor (CSTF). CSTF is involved in the polyadenylation and 3'end cleavage of pre-mRNAs. Similar to mammalian G protein beta subunits, this protein contains transducin-like repeats. Several transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008],

• Function：
• domain:N-terminus mediates homodimerization.,domain:The WD6 domain is required for interaction with BARD1. WD domains are responsible for interaction with CSTF3.,function:One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA.,PTM:The N-terminus is blocked.,similarity:Contains 6 WD repeats.,subunit:Homodimer. The CSTF complex is composed of CSTF1 (50 kDa subunit), CSTF2 (64 kDa subunit) and CSTF3 (77 kDa subunit). Interacts directly with CSTF3. Interacts with BARD1.,

• Subcellular Location：
• Nucleus .

• Expression：
• Muscle,Testis,

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