• Target：
• CYP2S1

• Fields：
• >>Retinol metabolism;>>Metabolism of xenobiotics by cytochrome P450;>>Metabolic pathways

• Gene Name：
• CYP2S1

• Protein Name：
• Cytochrome P450 2S1

• Human Gene Id：
• 29785

• Human Swiss Prot No：
• Q96SQ9

• Mouse Gene Id：
• 74134

• Mouse Swiss Prot No：
• Q9DBX6

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human Cytochrome P450 2S1. AA range:181-230

• Specificity：
• CYP2S1 Polyclonal Antibody detects endogenous levels of CYP2S1 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• CYP2S1;Cytochrome P450 2S1;CYPIIS1

• Observed Band(KD)：
• 56kD

• Background：
• This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. [provided by RefSeq, Jul 2008],

• Function：
• catalytic activity:RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.,cofactor:Heme group.,function:Has a potential importance for extrahepatic xenobiotic metabolism.,similarity:Belongs to the cytochrome P450 family.,tissue specificity:High level of expression in trachea, lung, stomach, small intestine, and spleen.,

• Subcellular Location：
• Endoplasmic reticulum membrane ; Peripheral membrane protein . Microsome membrane ; Peripheral membrane protein .

• Expression：
• Expressed at higher levels in extrahepatic tissues including trachea, lung, stomach, small intestine, colon, kidney, breast, placenta and spleen (PubMed:11181079, PubMed:12711469). Expressed in peripheral blood leukocytes (PubMed:11181079). Constitutively expressed in skin (at protein level) (PubMed:12711469).

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