• Target：
• DBP

• Gene Name：
• GC

• Protein Name：
• Vitamin D-binding protein

• Human Gene Id：
• 2638

• Human Swiss Prot No：
• P02774

• Mouse Swiss Prot No：
• P21614

• Immunogen：
• Synthesized peptide derived from DBP . at AA range: 90-170

• Specificity：
• DBP Polyclonal Antibody detects endogenous levels of DBP protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• GC;Vitamin D-binding protein;DBP;VDB;Gc-globulin;Group-specific component

• Observed Band(KD)：
• 55kD

• Background：
• The protein encoded by this gene belongs to the albumin gene family. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It binds to vitamin D and its plasma metabolites and transports them to target tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011],

• Function：
• function:Multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid, and urine and on the surface of many cell types. In plasma, it carries the vitamin D sterols and prevents polymerization of actin by binding its monomers. DBP associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor on the membranes of T-lymphocytes.,polymorphism:Over 80 variants of human DBP have been identified. The three most common alleles are called GC*1F, GC*1S, and GC*2. The sequence shown is that of the GC*2 allele.,similarity:Belongs to the ALB/AFP/VDB family.,similarity:Contains 3 albumin domains.,

• Subcellular Location：
• Secreted .

• Expression：
• Expressed in the liver. Found in plasma, ascites, cerebrospinal fluid and urine.

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