• Target：
• Desmin

• Fields：
• >>Hypertrophic cardiomyopathy;>>Arrhythmogenic right ventricular cardiomyopathy;>>Dilated cardiomyopathy

• Gene Name：
• DES

• Protein Name：
• Desmin

• Human Gene Id：
• 1674

• Human Swiss Prot No：
• P17661

• Mouse Gene Id：
• 13346

• Mouse Swiss Prot No：
• P31001

• Rat Gene Id：
• 64362

• Rat Swiss Prot No：
• P48675

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human Desmin. AA range:421-470

• Specificity：
• Desmin Polyclonal Antibody detects endogenous levels of Desmin protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• DES;Desmin

• Observed Band(KD)：
• 55kD

• Background：
• This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. [provided by RefSeq, Jul 2008],

• Function：
• disease:Defects in DES are the cause of cardiomyopathy dilated type 1I (CMD1I) [MIM:604765]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.,disease:Defects in DES are the cause of desmin-related cardio-skeletal myopathy (CSM) [MIM:601419]; also known as desmin-related myopathy (DRM). CSM is characterized by skeletal muscle weakness associated with cardiac conduction blocks, arrhythmias, restrictive heart failure, and by intracytoplasmic accumulation of desmin-reactive deposits in cardiac and skeletal muscle cells. A desmin-related myopathy can have a distal onset, it is then known as hereditary distal myopathy (HDM).,disease:Defects in DES are the cause of neurogenic scapuloperoneal syndrome Kaeser type (Kaeser syndrome) [MIM:181400].

• Subcellular Location：
• Cytoplasmic

• Expression：
• Muscle,Skeletal muscle,

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The PI3K/p-Akt signaling pathway participates in calcitriol ameliorating podocyte injury in DN rats. METABOLISM-CLINICAL AND EXPERIMENTAL Metabolism. 2014 Oct;63:1324 WB Rat Renal tissues

Podocyte-specific Rac1 deficiency ameliorates podocyte damage and proteinuria in STZ-induced diabetic nephropathy in mice. Cell Death & Disease Cell Death Dis. 2018 Mar;9(3):1-15 WB Mouse podocytes

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PDGF-mediated PI3K/AKT/β-catenin signaling regulates gap junctions in corpus cavernosum smooth muscle cells. EXPERIMENTAL CELL RESEARCH Exp Cell Res. 2018 Jan;362:252 IF Rat 1:100 SMCs

Fyn Mediates High Glucose-Induced Actin Cytoskeleton Reorganization of Podocytes via Promoting ROCK Activation In Vitro. Journal of Diabetes Research J Diabetes Res. 2016;2016:5671803 IF Mouse podocytes

Hu, Mengsi, et al. "Lnc RNA MALAT 1 is dysregulated in diabetic nephropathy and involved in high glucose‐induced podocyte injury via its interplay with β‐catenin." Journal of cellular and molecular medicine 21.11 (2017): 2732-2747.

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