• Target：
• DHA Kinase

• Fields：
• >>Fructose and mannose metabolism;>>Glycerolipid metabolism;>>Metabolic pathways;>>Carbon metabolism;>>RIG-I-like receptor signaling pathway

• Gene Name：
• DAK

• Protein Name：
• Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase

• Human Gene Id：
• 26007

• Human Swiss Prot No：
• Q3LXA3

• Mouse Gene Id：
• 225913

• Mouse Swiss Prot No：
• Q8VC30

• Rat Gene Id：
• 361730

• Rat Swiss Prot No：
• Q4KLZ6

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human DAK. AA range:91-140

• Specificity：
• DHA Kinase Polyclonal Antibody detects endogenous levels of DHA Kinase protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:200 - 1:1000. ELISA: 1:20000.. IF 1:20-50

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• DAK;Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase;cyclizing

• Observed Band(KD)：
• 59kD

• Background：
• This gene is a member of the family of dihydroxyacetone kinases, which have a protein structure distinct from other kinases. The product of this gene phosphorylates dihydroxyacetone, and also catalyzes the formation of riboflavin 4',5'-phosphate (aka cyclin FMN) from FAD. Several alternatively spliced transcript variants have been identified, but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008],

• Function：
• catalytic activity:ATP + glycerone = ADP + glycerone phosphate.,catalytic activity:FAD = AMP + riboflavin cyclic-4',5'-phosphate.,cofactor:Magnesium.,cofactor:Manganese or cobalt; for FAD-AMP lyase activity.,enzyme regulation:Each activity is inhibited by the substrate(s) of the other.,function:Catalyzes both the phosphorylation of dihydroxyacetone and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate.,similarity:Belongs to the dihydroxyacetone kinase (DAK) family.,similarity:Contains 1 DAK1 (dihydroxyacetone kinase subunit 1) domain.,similarity:Contains 1 DAK2 (dihydroxyacetone kinase subunit 2) domain.,subunit:Homodimer.,

• Subcellular Location：
• nucleus,cytosol,extracellular exosome,

• Expression：
• Detected in erythrocytes (at protein level).

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