DR4 Polyclonal Antibody

    • Catalog No.：YT1410
    • Applications：WB;IF;ELISA
    • Reactivity：Human;Monkey
      • Target：
      • DR4
      • Fields：
      • >>Cytokine-cytokine receptor interaction;>>Viral protein interaction with cytokine and cytokine receptor;>>p53 signaling pathway;>>Apoptosis;>>Necroptosis;>>Natural killer cell mediated cytotoxicity;>>Pathogenic Escherichia coli infection;>>Salmonella infection;>>Influenza A;>>Lipid and atherosclerosis
      • Gene Name：
      • TNFRSF10A
      • Protein Name：
      • Tumor necrosis factor receptor superfamily member 10A
      • Human Gene Id：
      • 8797
      • Human Swiss Prot No：
      • O00220
      • Immunogen：
      • The antiserum was produced against synthesized peptide derived from human TNFRSF10A. AA range:401-450
      • Specificity：
      • DR4 Polyclonal Antibody detects endogenous levels of DR4 protein.
      • Formulation：
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source：
      • Polyclonal, Rabbit,IgG
      • Dilution：
      • WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.
      • Purification：
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration：
      • 1 mg/ml
      • Storage Stability：
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name：
      • TNFRSF10A;APO2;DR4;TRAILR1;Tumor necrosis factor receptor superfamily member 10A;Death receptor 4;TNF-related apoptosis-inducing ligand receptor 1;TRAIL receptor 1;TRAIL-R1;CD antigen CD261
      • Observed Band(KD)：
      • 50kD
      • Background：
      • The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008],
      • Function：
      • function:Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.,similarity:Contains 1 death domain.,similarity:Contains 3 TNFR-Cys repeats.,subunit:Can interact with TRADD and RIP. Interacts with ARAP1.,tissue specificity:Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K562 erythroleukemia cells, MCF7 breast carcinoma cells and activated T-cells.,
      • Subcellular Location：
      • Cell membrane ; Single-pass type I membrane protein . Membrane raft . Cytoplasm, cytosol . Palmitoylation is required for association with membranes. .
      • Expression：
      • Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells.
      • Products Images
      • Western Blot analysis of various cells using DR4 Polyclonal Antibody
      • Western Blot analysis of Jurkat cells using DR4 Polyclonal Antibody

      Attributes

      • Code：
      • YT1410
      • Size
      • 40μL / 100μL / 200μL
      • Price$：
      • 150 / 280 / 450
      • Delivery：
      • 2024-05-20
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