• Target：
• Endo180

• Fields：
• >>Phagosome;>>Tuberculosis

• Gene Name：
• MRC2

• Protein Name：
• C-type mannose receptor 2

• Human Gene Id：
• 9902

• Human Swiss Prot No：
• Q9UBG0

• Mouse Gene Id：
• 17534

• Mouse Swiss Prot No：
• Q64449

• Rat Gene Id：
• 498011

• Rat Swiss Prot No：
• Q4TU93

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human MRC2. AA range:121-170

• Specificity：
• Endo180 Polyclonal Antibody detects endogenous levels of Endo180 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• MRC2;CLEC13E;ENDO180;KIAA0709;UPARAP;C-type mannose receptor 2;C-type lectin domain family 13 member E;Endocytic receptor 180;Macrophage mannose receptor 2;Urokinase-type plasminogen activator receptor-associated protein;UPAR-asso

• Observed Band(KD)：
• 167kD

• Background：
• mannose receptor C type 2(MRC2) Homo sapiens This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease. [provided by RefSeq, Feb 2012],

• Function：
• domain:C-type lectin domains 3 to 8 are not required for calcium-dependent binding of mannose, fucose and N-acetylglucosamine. C-type lectin domain 2 is responsible for sugar-binding in a calcium-dependent manner.,domain:Fibronectin type-II domain mediates collagen-binding.,domain:Ricin B-type lectin domain contacts with the second C-type lectin domain.,function:May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as

• Subcellular Location：
• Membrane; Single-pass type I membrane protein.

• Expression：
• Ubiquitous with low expression in brain, placenta, lung, kidney, pancreas, spleen, thymus and colon. Expressed in endothelial cells, fibroblasts and macrophages. Highly expressed in fetal lung and kidney.

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