Fatty Acid Synthase Polyclonal Antibody

  • Catalog No.：YT1683
  • Applications：WB;IHC;IF;ELISA
  • Reactivity：Human
    • Target：
    • Fatty Acid Synthase
    • Fields：
    • >>Fatty acid biosynthesis;>>Metabolic pathways;>>Fatty acid metabolism;>>AMPK signaling pathway;>>Insulin signaling pathway;>>Alcoholic liver disease
    • Gene Name：
    • FASN
    • Protein Name：
    • Fatty acid synthase
    • Human Gene Id：
    • 2194
    • Human Swiss Prot No：
    • P49327
    • Mouse Swiss Prot No：
    • P19096
    • Immunogen：
    • The antiserum was produced against synthesized peptide derived from human Fatty Acid Synthase. AA range:1478-1527
    • Specificity：
    • Fatty Acid Synthase Polyclonal Antibody detects endogenous levels of Fatty Acid Synthase protein.
    • Formulation：
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source：
    • Polyclonal, Rabbit,IgG
    • Dilution：
    • IHC: 100-300.WB 1:500 - 1:2000. ELISA: 1:10000.. IF 1:50-200
    • Purification：
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • Concentration：
    • 1 mg/ml
    • Storage Stability：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Other Name：
    • FASN;FAS;Fatty acid synthase
    • Observed Band(KD)：
    • 273kD
    • Background：
    • The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008],
    • Function：
    • catalytic activity:(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP(+) = 3-oxoacyl-[acyl-carrier-protein] + NADPH.,catalytic activity:(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] = hexadec-2-enoyl-[acyl-carrier-protein] + H(2)O.,catalytic activity:Acetyl-CoA + [acyl-carrier-protein] = CoA + acetyl-[acyl-carrier-protein].,catalytic activity:Acetyl-CoA + n malonyl-CoA + 2n NADPH = a long-chain fatty acid + (n+1) CoA + n CO(2) + 2n NADP(+).,catalytic activity:Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO(2) + [acyl-carrier-protein].,catalytic activity:Acyl-[acyl-carrier-protein] + NADP(+) = trans-2,3-dehydroacyl-[acyl-carrier-protein] + NADPH.,catalytic activity:Malonyl-CoA + [acyl-carrier-protein] = CoA + malonyl-[acyl-carrier-protein].,catalytic activity:Oleoyl-[acyl-carrier-protein] + H(2)O = [acyl-carrier-protein] + oleate.,functi
    • Subcellular Location：
    • Cytoplasm . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
    • Expression：
    • Ubiquitous. Prominent expression in brain, lung, liver and mammary gland.

    Attributes

    • Code：
    • YT1683
    • Size
    • 40μL / 100μL / 200μL
    • Price$：
    • 150 / 280 / 450
    • Delivery：
    • 2024-12-24
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