• Target：
• Frizzled-5

• Fields：
• >>mTOR signaling pathway;>>Wnt signaling pathway;>>Hippo signaling pathway;>>Signaling pathways regulating pluripotency of stem cells;>>Melanogenesis;>>Cushing syndrome;>>Alzheimer disease;>>Pathways of neurodegeneration - multiple diseases;>>Human papillomavirus infection;>>Pathways in cancer;>>Proteoglycans in cancer;>>Basal cell carcinoma;>>Breast cancer;>>Hepatocellular carcinoma;>>Gastric cancer

• Gene Name：
• FZD5

• Protein Name：
• Frizzled-5

• Human Gene Id：
• 7855

• Human Swiss Prot No：
• Q13467

• Mouse Gene Id：
• 14367

• Mouse Swiss Prot No：
• Q9EQD0

• Rat Gene Id：
• 317674

• Rat Swiss Prot No：
• Q8CHL0

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human FZD5. AA range:461-510

• Specificity：
• Frizzled-5 Polyclonal Antibody detects endogenous levels of Frizzled-5 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• FZD5;C2orf31;Frizzled-5;Fz-5;hFz5;FzE5

• Observed Band(KD)：
• 65kD

• Background：
• frizzled class receptor 5(FZD5) Homo sapiens Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD5 protein is believed to be the receptor for the Wnt5A ligand. [provided by RefSeq, Jul 2008],

• Function：
• domain:Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway.,domain:The FZ domain is involved in binding with Wnt ligands.,domain:The PDZ-binding motif mediates interaction with GOPC.,function:Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellul

• Subcellular Location：
• Cell membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein . Cell junction, synapse . Perikaryon . Cell projection, dendrite . Cell projection, axon . Localized at the plasma membrane and also found at the Golgi. .

• Expression：
• Oesophageal carcinoma,Retina,

Hu, Feihu, Ting Chen, and Wei Wang. "Effects of polyethylene oxide and poly (3-hydroxybutyrate-co-3-hydroxyvalerate) nanofibrous substrate on omental adipose-derived mesenchymal stem cell neuronal differentiation and peripheral nerve regeneration." RSC Advances 7.68 (2017): 42833-42844.

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