• Target：
• FRP-2

• Fields：
• >>Wnt signaling pathway

• Gene Name：
• SFRP2

• Protein Name：
• Secreted frizzled-related protein 2

• Human Gene Id：
• 6423

• Human Swiss Prot No：
• Q96HF1

• Mouse Gene Id：
• 20319

• Mouse Swiss Prot No：
• P97299

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human SFRP2. AA range:119-168

• Specificity：
• FRP-2 Polyclonal Antibody detects endogenous levels of FRP-2 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• SFRP2;FRP2;SARP1;FKSG12;Secreted frizzled-related protein 2;FRP-2;sFRP-2;Secreted apoptosis-related protein 1;SARP-1

• Observed Band(KD)：
• 30kD

• Background：
• This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer. [provided by RefSeq, Jul 2008],

• Function：
• domain:The FZ domain is involved in binding with Wnt ligands.,function:Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis.,similarity:Belongs to the secreted frizzled-related protein (sFRP) family.,similarity:Contains 1 FZ (frizzled) domain.,similarity:Contains 1 NTR domain.,tissue specificity:Expressed in adipose tissue, heart, brain, skeletal muscle, pancreas, thymus, prostate, testis, ovary, small intestine and colon. Highest levels in adipose tissue, small intestine and colon.,

• Subcellular Location：
• Secreted .

• Expression：
• Expressed in adipose tissue, heart, brain, skeletal muscle, pancreas, thymus, prostate, testis, ovary, small intestine and colon. Highest levels in adipose tissue, small intestine and colon.

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