• Target：
• GABAA Rβ2

• Fields：
• >>Neuroactive ligand-receptor interaction;>>Retrograde endocannabinoid signaling;>>Serotonergic synapse;>>GABAergic synapse;>>Morphine addiction;>>Nicotine addiction

• Gene Name：
• GABRB2

• Protein Name：
• Gamma-aminobutyric acid receptor subunit beta-2

• Human Gene Id：
• 2561

• Human Swiss Prot No：
• P47870

• Mouse Gene Id：
• 14401

• Mouse Swiss Prot No：
• P63137

• Rat Gene Id：
• 25451

• Rat Swiss Prot No：
• P63138

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human GABAA Rbeta2. AA range:382-431

• Specificity：
• GABAA Rβ2 Polyclonal Antibody detects endogenous levels of GABAA Rβ2 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000 IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• GABRB2;Gamma-aminobutyric acid receptor subunit beta-2;GABA(A) receptor subunit beta-2

• Molecular Weight(Da)：
• 55kD

• Background：
• The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 2 subunit. It is mapped to chromosome 5q34 in a cluster comprised of genes encoding alpha 1 and gamma 2 subunits of the GABA A receptor. Alternative splicing of this gene generates 2 transcript variants, differing by a 114 bp insertion. [provided by RefSeq, Jul 2008],

• Function：
• function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.,online information:Forbidden fruit - Issue 56 of March 2005,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Binds UBQLN1.,

• Subcellular Location：
• Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Cytoplasmic vesicle membrane .

• Expression：
• Isoform 1 and isoform 2 show reduced expression in schizophrenic brain. Isoform 3 shows increased expression in schizophrenic and bipolar disorder brains while isoform 4 shows reduced expression.

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