• Target：
• GABAB R1

• Fields：
• >>cAMP signaling pathway;>>Neuroactive ligand-receptor interaction;>>GABAergic synapse;>>Taste transduction;>>Estrogen signaling pathway;>>GnRH secretion;>>Morphine addiction

• Gene Name：
• GABBR1

• Protein Name：
• Gamma-aminobutyric acid type B receptor subunit 1

• Human Gene Id：
• 2550

• Human Swiss Prot No：
• Q9UBS5

• Mouse Gene Id：
• 54393

• Mouse Swiss Prot No：
• Q9WV18

• Rat Gene Id：
• 81657

• Rat Swiss Prot No：
• Q9Z0U4

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human GABBR1. AA range:891-940

• Specificity：
• GABAB R1 Polyclonal Antibody detects endogenous levels of GABAB R1 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• GABBR1;GPRC3A;Gamma-aminobutyric acid type B receptor subunit 1;GABA-B receptor 1;GABA-B-R1;GABA-BR1;GABABR1;Gb1

• Observed Band(KD)：
• 108kD

• Background：
• This gene encodes a receptor for gamma-aminobutyric acid (GABA), which is the main inhibitory neurotransmitter in the mammalian central nervous system. This receptor functions as a heterodimer with GABA(B) receptor 2. Defects in this gene may underlie brain disorders such as schizophrenia and epilepsy. Alternative splicing generates multiple transcript variants, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jan 2016],

• Function：
• alternative products:Isoforms corresponding to the full receptor are essentially found in the central nervous system (CNS),cofactor:Calcium. Required for high affinity binding to GABA.,domain:Alpha-helical parts of the C-terminal intracellular region mediate heterodimeric interaction with GABA-B receptor 2. The linker region between the transmembrane domain 3 (TM3) and the transmembrane domain 4 (TM4) probably play a role in the specificity for G-protein coupling.,function:Isoform 1E function may be to regulate the availability of functional GABA-B-R1A/GABA-B-R2 heterodimers by competing for GABA-B-R2 dimerization. This could explain the observation that certain small molecule ligands exhibit differential affinity for central versus peripheral sites.,function:Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phos

• Subcellular Location：
• Cell membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein . Cell projection, dendrite . Colocalizes with ATF4 in hippocampal neuron dendritic membranes (By similarity). Coexpression of GABBR1 and GABBR2 is required for GABBR1 maturation and transport to the plasma membrane (PubMed:15617512). .; [Isoform 1E]: Secreted .

• Expression：
• Highly expressed in brain (PubMed:9844003, PubMed:9753614, PubMed:9872744). Weakly expressed in heart, small intestine and uterus. Isoform 1A: Mainly expressed in granular cell and molecular layer (PubMed:9844003). Isoform 1B: Mainly expressed in Purkinje cells (PubMed:9844003). Isoform 1E: Predominantly expressed in peripheral tissues as kidney, lung, trachea, colon, small intestine, stomach, bone marrow, thymus and mammary gland (PubMed:10906333).

Effects of electroacupuncture on the levels of retinal gamma-aminobutyric acid and its receptors in a guinea pig model of lens-induced myopia. NEUROSCIENCE Neuroscience. 2015 Feb;287:164 WB Guinea pig 1:200 eyes

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