• Target：
• GCKR

• Gene Name：
• GCKR

• Protein Name：
• Glucokinase regulatory protein

• Human Gene Id：
• 2646

• Human Swiss Prot No：
• Q14397

• Mouse Gene Id：
• 231103

• Mouse Swiss Prot No：
• Q91X44

• Rat Gene Id：
• 25658

• Rat Swiss Prot No：
• Q07071

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human Glucokinase Regulator. AA range:211-260

• Specificity：
• GCKR Polyclonal Antibody detects endogenous levels of GCKR protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• GCKR;Glucokinase regulatory protein;Glucokinase regulator

• Observed Band(KD)：
• 68kD

• Background：
• This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY). [provided by RefSeq, Jul 2008],

• Function：
• function:Inhibits glucokinase by forming an inactive complex with this enzyme.,similarity:Belongs to the GCKR family.,similarity:Contains 1 SIS domain.,tissue specificity:Found in liver and pancreas. Not detected in muscle, brain, heart, thymus, intestine, uterus, adipose tissue, kidney, adrenal, lung or spleen.,

• Subcellular Location：
• Cytoplasm . Nucleus . Mitochondrion . Under low glucose concentrations, GCKR associates with GCK and the inactive complex is recruited to the hepatocyte nucleus. .

• Expression：
• Found in liver and pancreas. Not detected in muscle, brain, heart, thymus, intestine, uterus, adipose tissue, kidney, adrenal, lung or spleen.

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