• Target：
• GLK

• Fields：
• >>MAPK signaling pathway

• Gene Name：
• MAP4K3

• Protein Name：
• Mitogen-activated protein kinase kinase kinase kinase 3

• Human Gene Id：
• 8491

• Human Swiss Prot No：
• Q8IVH8

• Mouse Swiss Prot No：
• Q99JP0

• Rat Gene Id：
• 170920

• Rat Swiss Prot No：
• Q924I2

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human MAP4K3. AA range:10-59

• Specificity：
• GLK Polyclonal Antibody detects endogenous levels of GLK protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• MAP4K3;RAB8IPL1;Mitogen-activated protein kinase kinase kinase kinase 3;Germinal center kinase-related protein kinase;GLK;MAPK/ERK kinase kinase kinase 3;MEK kinase kinase 3;MEKKK 3

• Observed Band(KD)：
• 101kD

• Background：
• mitogen-activated protein kinase kinase kinase kinase 3(MAP4K3) Homo sapiens This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012],

• Function：
• catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,function:May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.,similarity:Contains 1 CNH domain.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with SH3GL2. Interaction appears to regulate MAP4K3-mediated JNK activation.,tissue specificity:Ubiquitously expressed in all tissues examined, with high levels in heart, brain, placenta, skeletal muscle, kidney and pancreas and lower levels in lung and liver.,

• Subcellular Location：
• intracellular,cytoplasm,

• Expression：
• Ubiquitously expressed in all tissues examined, with high levels in heart, brain, placenta, skeletal muscle, kidney and pancreas and lower levels in lung and liver.

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