• Target：
• GRK 3

• Fields：
• >>Chemokine signaling pathway;>>Endocytosis;>>Hedgehog signaling pathway;>>Glutamatergic synapse;>>Olfactory transduction;>>Morphine addiction

• Gene Name：
• ADRBK2

• Protein Name：
• Beta-adrenergic receptor kinase 2

• Human Gene Id：
• 157

• Human Swiss Prot No：
• P35626

• Mouse Gene Id：
• 320129

• Mouse Swiss Prot No：
• Q3UYH7

• Rat Gene Id：
• 25372

• Rat Swiss Prot No：
• P26819

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human GRK3. AA range:361-410

• Specificity：
• GRK 3 Polyclonal Antibody detects endogenous levels of GRK 3 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• ADRBK2;BARK2;GRK3;Beta-adrenergic receptor kinase 2;Beta-ARK-2;G-protein-coupled receptor kinase 3

• Observed Band(KD)：
• 80kD

• Background：
• The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function. [provided by RefSeq, Jul 2008],

• Function：
• catalytic activity:ATP + [beta-adrenergic receptor] = ADP + [beta-adrenergic receptor] phosphate.,function:Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 RGS domain.,

• Subcellular Location：
• Cell junction, synapse, postsynapse . Cell junction, synapse, presynapse .

• Expression：
• Brain,Ovary,

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