HDAC1 Polyclonal Antibody

  • Catalog No.:YT2112
  • Applications:WB;IHC;IF;ELISA
  • Reactivity:Human;Mouse;Rat
    • Target:
    • HDAC1
    • Fields:
    • >>Cell cycle;>>Longevity regulating pathway - multiple species;>>Notch signaling pathway;>>Neutrophil extracellular trap formation;>>Thyroid hormone signaling pathway;>>Huntington disease;>>Amphetamine addiction;>>Alcoholism;>>Human papillomavirus infection;>>Epstein-Barr virus infection;>>Pathways in cancer;>>Transcriptional misregulation in cancer;>>Viral carcinogenesis;>>MicroRNAs in cancer;>>Chronic myeloid leukemia
    • Gene Name:
    • HDAC1
    • Protein Name:
    • Histone deacetylase 1
    • Human Gene Id:
    • 3065
    • Human Swiss Prot No:
    • Q13547
    • Mouse Swiss Prot No:
    • O09106
    • Immunogen:
    • The antiserum was produced against synthesized peptide derived from human HDAC1. AA range:387-436
    • Specificity:
    • HDAC1 Polyclonal Antibody detects endogenous levels of HDAC1 protein.
    • Formulation:
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source:
    • Polyclonal, Rabbit,IgG
    • Dilution:
    • WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
    • Purification:
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • Concentration:
    • 1 mg/ml
    • Storage Stability:
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Other Name:
    • HDAC1;RPD3L1;Histone deacetylase 1;HD1
    • Observed Band(KD):
    • 55kD
    • Background:
    • Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008],
    • Function:
    • catalytic activity:Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.,function:Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.,PTM:Phosphorylation on Ser-421 and Ser-423 promotes enzymatic activity and interactions with NuRD and SIN3 complexes.,PTM:Sumoylated on Lys-444 and Lys-476; which promotes enzymatic activity. Desumoylated by SENP1.,similarity:Belongs to the histone deacetylase family. Type 1 subfamily.,subunit:Part of the core histone deacetylase (HDAC) complex composed of HDAC1, HDAC2, RBBP4 and RBBP7. The core complex associates
    • Subcellular Location:
    • Nucleus .
    • Expression:
    • Ubiquitous, with higher levels in heart, pancreas and testis, and lower levels in kidney and brain.