• Target：
• HoxA5

• Gene Name：
• HOXA5

• Protein Name：
• Homeobox protein Hox-A5

• Human Gene Id：
• 3202

• Human Swiss Prot No：
• P20719

• Mouse Gene Id：
• 15402

• Mouse Swiss Prot No：
• P09021

• Rat Swiss Prot No：
• P52949

• Immunogen：
• Synthesized peptide derived from the N-terminal region of human HoxA5.

• Specificity：
• HoxA5 Polyclonal Antibody detects endogenous levels of HoxA5 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• HOXA5;HOX1C;Homeobox protein Hox-A5;Homeobox protein Hox-1C

• Observed Band(KD)：
• 40kD

• Background：
• In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Methylation of this gene may result in the loss of its expression and, since the encoded protein upregulates the tumor suppressor p53, this protein may play an important role in tumorigenesis. [provided by RefSeq, Jul 2008],

• Function：
• developmental stage:Expressed during embryogenesis and in adult kidney.,function:Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3'.,similarity:Belongs to the Antp homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,

• Subcellular Location：
• Nucleus.

• Expression：
• Ovary,

Knockdown of homeobox A5 by small hairpin RNA inhibits proliferation and enhances cytarabine chemosensitivity of acute myeloid leukemia cells. Molecular Medicine Reports Mol Med Rep. 2015 Nov;12(5):6861-6866 WB Human 1:1000 U937 cell

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