Ksr2 Polyclonal Antibody

    • Catalog No.:YT2497
    • Applications:WB,IHC-p,IF/ICC,ELISA
    • Reactivity:Human,Mouse
      • Gene Name:
      • KSR2
      • Protein Name:
      • Kinase suppressor of Ras 2
      • Human Swiss Prot No:
      • Q6VAB6
      • Mouse Swiss Prot No:
      • Q3UVC0
      • Immunogen:
      • The antiserum was produced against synthesized peptide derived from human KSR2. AA range:671-720
      • Specificity:
      • Ksr2 Polyclonal Antibody detects endogenous levels of Ksr2 protein.
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Rabbit
      • Dilution:
      • Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.
      • Purification:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -20°C/1 year
      • Other Name:
      • KSR2; Kinase suppressor of Ras 2; hKSR2
      • MolecularWeight(Da):
      • 107632
      • Observed Band(KD):
      • 108
      • Background:
      • domain:The protein kinase domain is predicted to be catalytically inactive.,function:Location-regulated scaffold connecting MEK to RAF. Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.,PTM:Phosphorylated on Ser-474 by MARK3.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.,similarity:Contains 1 phorbol-ester/DAG-type zinc finger.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with MAP2K1, MAP3K8, MAPK, RAS and RAF.,tissue specificity:Mainly expressed in brain and kidney.,
      • Function:
      • domain:The protein kinase domain is predicted to be catalytically inactive.,function:Location-regulated scaffold connecting MEK to RAF. Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.,PTM:Phosphorylated on Ser-474 by MARK3.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.,similarity:Contains 1 phorbol-ester/DAG-type zinc finger.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with MAP2K1, MAP3K8, MAPK, RAS and RAF.,tissue specificity:Mainly expressed in brain and kidney.,
      • Subcellular Location:
      • intracellular,cytoplasm,membrane,
      • Expression:
      • Testis,
      • Products Images
      • Immunofluorescence analysis of HeLa cells, using KSR2 Antibody. The picture on the right is blocked with the synthesized peptide.
      • Western blot analysis of lysates from 293 cells, using KSR2 Antibody. The lane on the right is blocked with the synthesized peptide.