• Target：
• MEK Kinase-6

• Fields：
• >>MAPK signaling pathway

• Gene Name：
• MAP3K6

• Protein Name：
• Mitogen-activated protein kinase kinase kinase 6

• Human Gene Id：
• 9064

• Human Swiss Prot No：
• O95382

• Mouse Gene Id：
• 53608

• Mouse Swiss Prot No：
• Q9WTR2

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human MAP3K6. AA range:281-330

• Specificity：
• MEK Kinase-6 Polyclonal Antibody detects endogenous levels of MEK Kinase-6 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• MAP3K6;ASK2;MAPKKK6;MEKK6;Mitogen-activated protein kinase kinase kinase 6;Apoptosis signal-regulating kinase 2

• Molecular Weight(Da)：
• 143kD

• Background：
• This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014],

• Function：
• catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation on Thr-806. Catalytically active only when complexed with MAP3K5, with MAP3K5 supporting the stability and the active configuration of MAP3K6 and MAP3K6 activating MAP3K5 by direct phosphorylation.,function:Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Binds both upstream activators and downstream substrates in multimolecular complexes.,

• Subcellular Location：
• intracellular,

• Expression：
• Brain,PCR rescued clones,Skin,

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