OAT Polyclonal Antibody

  • Catalog No.：YT3219
  • Applications：WB;ELISA
  • Reactivity：Human;Mouse;Rat
    • Target：
    • OAT
    • Fields：
    • >>Arginine and proline metabolism;>>Metabolic pathways
    • Gene Name：
    • OAT
    • Protein Name：
    • Ornithine aminotransferase mitochondrial
    • Human Gene Id：
    • 4942
    • Human Swiss Prot No：
    • P04181
    • Mouse Swiss Prot No：
    • P29758
    • Immunogen：
    • Synthesized peptide derived from OAT . at AA range: 100-180
    • Specificity：
    • OAT Polyclonal Antibody detects endogenous levels of OAT protein.
    • Formulation：
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source：
    • Polyclonal, Rabbit,IgG
    • Dilution：
    • WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.
    • Purification：
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • Concentration：
    • 1 mg/ml
    • Storage Stability：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Other Name：
    • OAT;Ornithine aminotransferase; mitochondrial;Ornithine delta-aminotransferase;Ornithine--oxo-acid aminotransferase
    • Observed Band(KD)：
    • 48kD
    • Background：
    • ornithine aminotransferase(OAT) Homo sapiens This gene encodes the mitochondrial enzyme ornithine aminotransferase, which is a key enzyme in the pathway that converts arginine and ornithine into the major excitatory and inhibitory neurotransmitters glutamate and GABA. Mutations that result in a deficiency of this enzyme cause the autosomal recessive eye disease Gyrate Atrophy. Alternatively spliced transcript variants encoding different isoforms have been described. Related pseudogenes have been defined on the X chromosome. [provided by RefSeq, Jan 2010],
    • Function：
    • catalytic activity:L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid.,cofactor:Pyridoxal phosphate.,disease:Defects in OAT are the cause of hyperornithinemia with gyrate atrophy of choroid and retina (HOGA) [MIM:258870]. HOGA is a slowly progressive blinding autosomal recessive disorder.,pathway:Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.,similarity:Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.,subunit:Homotetramer.,
    • Subcellular Location：
    • Mitochondrion matrix .
    • Expression：
    • Alzheimer cortex,Brain,Cerebral cortex,Kidney,Liver,Placenta,Subthalamic nucleus,Ut

    Attributes

    • Code：
    • YT3219
    • Size
    • 40μL / 100μL / 200μL
    • Price$：
    • 150 / 280 / 450
    • Delivery：
    • 2024-12-27
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