• Target：
• PAR-3

• Fields：
• >>Neuroactive ligand-receptor interaction;>>Complement and coagulation cascades

• Gene Name：
• F2RL2

• Protein Name：
• Proteinase-activated receptor 3

• Human Gene Id：
• 2151

• Human Swiss Prot No：
• O00254

• Mouse Swiss Prot No：
• O08675

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human F2RL2. AA range:38-87

• Specificity：
• PAR-3 Polyclonal Antibody detects endogenous levels of PAR-3 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• F2RL2;PAR3;Proteinase-activated receptor 3;PAR-3;Coagulation factor II receptor-like 2;Thrombin receptor-like 2

• Molecular Weight(Da)：
• 43kD

• Background：
• This gene encodes a member of the protease-activated receptor (PAR) family which is a subfamily of the seven transmembrane G protein-coupled cell surface receptor family. The encoded protein acts as a cofactor in the thrombin-mediated cleavage and activation of the protease-activated receptor family member PAR4. The encoded protein plays an essential role in hemostasis and thrombosis. Alternate splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Feb 2012],

• Function：
• function:Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis.,PTM:A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with INSC/inscuteable and probably GPSM2.,tissue specificity:Highest expression in the megakaryocytes of the bone marrow, lower in mature megakaryocytes, in platelets and in a variety of other tissues such as heart and gut.,

• Subcellular Location：
• Cell membrane; Multi-pass membrane protein.

• Expression：
• Highest expression in the megakaryocytes of the bone marrow, lower in mature megakaryocytes, in platelets and in a variety of other tissues such as heart and gut.

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