• Target：
• PinX1

• Gene Name：
• PINX1

• Protein Name：
• PIN2/TERF1-interacting telomerase inhibitor 1

• Human Gene Id：
• 54984

• Human Swiss Prot No：
• Q96BK5

• Mouse Swiss Prot No：
• Q9CZX5

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human PINX1. AA range:121-170

• Specificity：
• PinX1 Polyclonal Antibody detects endogenous levels of PinX1 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• PINX1;LPTL;LPTS;PIN2/TERF1-interacting telomerase inhibitor 1;Liver-related putative tumor suppressor;Pin2-interacting protein X1;Protein 67-11-3;TRF1-interacting protein 1

• Molecular Weight(Da)：
• 37kD

• Background：
• domain:The TID (telomerase inhibiting domain) domain is sufficient to bind TERT and inhibit its activity.,function:Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor.,similarity:Belongs to the PINX1 family.,similarity:Contains 1 G-patch domain.,subcellular location:In nucleoli and at telomere speckles.,subunit:Binds to MCRS1, TERT and TERF1.,tissue specificity:Ubiquitous; expressed at low levels. Not detectable in a number of hepatocarcinoma cell lines.,

• Function：
• domain:The TID (telomerase inhibiting domain) domain is sufficient to bind TERT and inhibit its activity.,function:Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor.,similarity:Belongs to the PINX1 family.,similarity:Contains 1 G-patch domain.,subcellular location:In nucleoli and at telomere speckles.,subunit:Binds to MCRS1, TERT and TERF1.,tissue specificity:Ubiquitous; expressed at low levels. Not detectable in a number of hepatocarcinoma cell lines.,

• Subcellular Location：
• Nucleus . Nucleus, nucleolus. Chromosome, telomere. Chromosome, centromere, kinetochore. Localizes in nucleoli, at telomere speckles and to the outer plate of kinetochores. Localization to the kinetochore is mediated by its central region and depends on NDC80 and CENPE.

• Expression：
• Ubiquitous; expressed at low levels. Not detectable in a number of hepatocarcinoma cell lines.

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