• Target：
• PREP-2

• Gene Name：
• PKNOX2

• Protein Name：
• Homeobox protein PKNOX2

• Human Gene Id：
• 63876

• Human Swiss Prot No：
• Q96KN3

• Mouse Gene Id：
• 208076

• Mouse Swiss Prot No：
• Q8BG99

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human PKNOX2. AA range:341-390

• Specificity：
• PREP-2 Polyclonal Antibody detects endogenous levels of PREP-2 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• PKNOX2;PREP2;Homeobox protein PKNOX2;Homeobox protein PREP-2;PBX/knotted homeobox 2

• Observed Band(KD)：
• 55kD

• Background：
• Homeodomain proteins are sequence-specific transcription factors that share a highly conserved DNA-binding domain and play fundamental roles in cell proliferation, differentiation, and death. PKNOX2 belongs to the TALE (3-amino acid loop extension) class of homeodomain proteins characterized by a 3-amino acid extension between alpha helices 1 and 2 within the homeodomain (Imoto et al., 2001 [PubMed 11549286]).[supplied by OMIM, Oct 2009],

• Function：
• similarity:Belongs to the TALE/MEIS homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,

• Subcellular Location：
• Nucleus .

• Expression：
• Brain,Small intestine,

The mechanism of mulberry leaves against renal tubular interstitial fibrosis through ERK1/2 signaling pathway was predicted by network pharmacology and validated in human tubular epithelial cells. PHYTOTHERAPY RESEARCH 2019 Jun 17 WB Human 1:400 HK-2 cell

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