• Target：
• PRX1

• Gene Name：
• PRRX1

• Protein Name：
• Paired mesoderm homeobox protein 1

• Human Gene Id：
• 5396

• Human Swiss Prot No：
• P54821

• Mouse Gene Id：
• 18933

• Mouse Swiss Prot No：
• P63013

• Rat Gene Id：
• 266813

• Rat Swiss Prot No：
• P63014

• Immunogen：
• Synthesized peptide derived from PRX1 . at AA range: 30-110

• Specificity：
• PRX1 Polyclonal Antibody detects endogenous levels of PRX1 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• PRRX1;PMX1;Paired mesoderm homeobox protein 1;Homeobox protein PHOX1;Paired-related homeobox protein 1;PRX-1

• Observed Band(KD)：
• 27kD

• Background：
• The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription co-activator, enhancing the DNA-binding activity of serum response factor, a protein required for the induction of genes by growth and differentiation factors. The protein regulates muscle creatine kinase, indicating a role in the establishment of diverse mesodermal muscle types. Alternative splicing yields two isoforms that differ in abundance and expression patterns. [provided by RefSeq, Jul 2008],

• Function：
• function:Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer.,similarity:Belongs to the paired homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,similarity:Contains 1 OAR domain.,

• Subcellular Location：
• Nucleus.

SIRT1 coordinates with the CRL4B complex to regulate pancreatic cancer stem cells to promote tumorigenesis. CELL DEATH AND DIFFERENTIATION Cell Death Differ. 2021 Jun;:1-15 WB Human PANC-1 cell

SIRT1 coordinates with the CRL4B complex to regulate pancreatic cancer stem cells to promote tumorigenesis. CELL DEATH AND DIFFERENTIATION Cell Death Differ. 2021 Jun;:1-15 WB Human PANC-1 cell， AsPC-1 cell

The rs7911488-T allele promotes the growth and metastasis of colorectal cancer through modulating miR-1307/PRRX1. Cell Death & Disease Cell Death Dis. 2020 Aug;11(8):1-14 WB Human SW480 cell， HCT-116 cell

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