• Target：
• PSMC3

• Fields：
• >>Proteasome;>>Alzheimer disease;>>Parkinson disease;>>Amyotrophic lateral sclerosis;>>Huntington disease;>>Spinocerebellar ataxia;>>Prion disease;>>Pathways of neurodegeneration - multiple diseases;>>Epstein-Barr virus infection

• Gene Name：
• PSMC3

• Protein Name：
• 26S protease regulatory subunit 6A

• Human Gene Id：
• 5702

• Human Swiss Prot No：
• P17980

• Mouse Gene Id：
• 19182

• Mouse Swiss Prot No：
• O88685

• Rat Gene Id：
• 29677

• Rat Swiss Prot No：
• Q63569

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human PRS6A. AA range:271-320

• Specificity：
• PSMC3 Polyclonal Antibody detects endogenous levels of PSMC3 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• PSMC3;TBP1;26S protease regulatory subunit 6A;26S proteasome AAA-ATPase subunit RPT5;Proteasome 26S subunit ATPase 3;Proteasome subunit P50;Tat-binding protein 1;TBP-1

• Observed Band(KD)：
• 45kD

• Background：
• proteasome 26S subunit, ATPase 3(PSMC3) Homo sapiens The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for bindi

• Function：
• function:The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). In case of HIV-1 infection, suppresses Tat-mediated transactivation.,PTM:Sumoylated by UBE2I in response to MEKK1-mediated stimuli.,similarity:Belongs to the AAA ATPase family.,subunit:May form a heterodimer with a related family member. Interacts with PAAF1. Interacts with HIV-1 Tat.,

• Subcellular Location：
• Cytoplasm . Nucleus . Colocalizes with TRIM5 in the cytoplasmic bodies. .

• Expression：
• Adipose tissue,Brain,Cajal-Retzius cell,Fetal brain cortex,Kidney,Lung,Peri

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