• Target：
• PTGR2

• Gene Name：
• PTGR2

• Protein Name：
• Prostaglandin reductase 2

• Human Gene Id：
• 145482

• Human Swiss Prot No：
• Q8N8N7

• Mouse Swiss Prot No：
• Q8VDQ1

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human ZADH1. AA range:181-230

• Specificity：
• PTGR2 Polyclonal Antibody detects endogenous levels of PTGR2 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• PTGR2;ZADH1;Prostaglandin reductase 2;PRG-2;15-oxoprostaglandin 13-reductase;Zinc-binding alcohol dehydrogenase domain-containing protein 1

• Observed Band(KD)：
• 35kD

• Background：
• This gene encodes an enzyme involved in the metabolism of prostaglandins. The encoded protein catalyzes the NADPH-dependent conversion of 15-keto-prostaglandin E2 to 15-keto-13,14-dihydro-prostaglandin E2. This protein may also be involved in regulating activation of the peroxisome proliferator-activated receptor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009],

• Function：
• catalytic activity:11-alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD(P)(+) = (5Z)-(13E)-11-alpha-hydroxy-9,15-dioxoprosta-5,13-dienoate + NAD(P)H.,cofactor:NADPH.,function:Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation.,similarity:Belongs to the NADP-dependent oxidoreductase L4BD family.,subunit:Monomer.,tissue specificity:Widely expressed.,

• Subcellular Location：
• Cytoplasm .

• Expression：
• Widely expressed.

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